Japan Digestive Disease Week 2025
International Poster Session2 (JDDW)
October 31, 10:18–10:58, Room 15 (Kobe International Exhibition Hall No.1 Building Digital Poster Venue)
IP-10_E
The Performance of the Endoscopic Grading of Gastric Intestinal Metaplasia (EGGIM) in Predicting Extensive Gastric Intestinal Metaplasia: A Meta-analysis and Systematic Review Travel Award
- 1
- University of Medicine and Pharmacy at Ho Chi Minh City
- 2
- Health Service Center, Hiroshima University
Objectives
The Endoscopic Grading of Gastric Intestinal Metaplasia (EGGIM) has emerged as a non-invasive alternative to the histopathology-based Operative Link on Gastric Intestinal Metaplasia (OLGIM) staging system. This study aimed to systematically review and meta-analyze the diagnostic performance of EGGIM for extensive GIM (OLGIM III-IV).
Methods
We conducted a systematic search of PubMed, Embase, Scopus, and Cochrane through September 2024 for original studies on the performance of EGGIM in detecting extensive GIM. The pooled diagnostic performance statistics of EGGIM were calculated using random-effect models.
Results
Of 41 records, six studies (1,108 patients) were included in the meta-analysis. With an EGGIM cutoff of >=5, the pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for detecting extensive GIM were 0.87 (95% CI: 0.83-0.91), 0.91 (95% CI: 0.89-0.93), 9.58 (95% CI: 6.37-14.42), and 0.13 (95% CI: 0.09-0.21), respectively. The weighted area under the curve (AUC) was 0.96 +- 0.01. Subgroup analyses by endoscopic imaging modality revealed the consistent performance of EGGIM.
Conclusions
An EGGIM score of >=5 shows high overall diagnostic accuracy for extensive GIM, providing a non-invasive, endoscopy-based alternative to histopathological staging. These findings support the use of EGGIM in endoscopic practice to stratify patients at risk of gastric cancer.
The Endoscopic Grading of Gastric Intestinal Metaplasia (EGGIM) has emerged as a non-invasive alternative to the histopathology-based Operative Link on Gastric Intestinal Metaplasia (OLGIM) staging system. This study aimed to systematically review and meta-analyze the diagnostic performance of EGGIM for extensive GIM (OLGIM III-IV).
Methods
We conducted a systematic search of PubMed, Embase, Scopus, and Cochrane through September 2024 for original studies on the performance of EGGIM in detecting extensive GIM. The pooled diagnostic performance statistics of EGGIM were calculated using random-effect models.
Results
Of 41 records, six studies (1,108 patients) were included in the meta-analysis. With an EGGIM cutoff of >=5, the pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for detecting extensive GIM were 0.87 (95% CI: 0.83-0.91), 0.91 (95% CI: 0.89-0.93), 9.58 (95% CI: 6.37-14.42), and 0.13 (95% CI: 0.09-0.21), respectively. The weighted area under the curve (AUC) was 0.96 +- 0.01. Subgroup analyses by endoscopic imaging modality revealed the consistent performance of EGGIM.
Conclusions
An EGGIM score of >=5 shows high overall diagnostic accuracy for extensive GIM, providing a non-invasive, endoscopy-based alternative to histopathological staging. These findings support the use of EGGIM in endoscopic practice to stratify patients at risk of gastric cancer.
- Index Term 1: EGGIM
- Index Term 2: Gastric intestinal metaplasia