Japan Digestive Disease Week 2025
International Poster Session12 (JDDW)
October 31, 14:32–15:20, Room 15 (Kobe International Exhibition Hall No.1 Building Digital Poster Venue)
IP-58_H
Prevention of Alcoholic Cirrhosis Using Alcohol Metabolism Gene Polymorphism Testing
- 1
- Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University School of Medicine
BACKGROUND AND AIMS: Genetic polymorphisms of alcohol-metabolizing enzymes ALDH2 and ADH1B influence the development of alcoholic cirrhosis. This study examined the association between these polymorphisms and patients' self-recognition of their genetic traits.
METHODS: We enrolled 83 cirrhosis patients (45 alcoholic, 38 non-alcoholic) and 26 healthy volunteers from our hospital (Jan 2024-Feb 2025). Subjects were categorized into five groups based on ALDH2 and ADH1B polymorphisms and asked to predict their genotype before actual analysis using dried saliva specimens.
RESULTS: Self-recognition accuracy was 71.1% in alcoholic cirrhosis, 84.2% in non-alcoholic cirrhosis, and 85.7% in healthy controls (p<0.05). ALDH2 wild-type was found in 93.3% of alcoholic cirrhosis patients and 28.9% of non-alcoholic cirrhosis patients (p<0.01). ADH1B wild-type was more frequent in alcoholic cirrhosis (11.1% vs. 2.6%, p<0.05). Among alcoholic cirrhosis patients, 8.8% had both wild-types and showed severe liver dysfunction.
CONCLUSIONS: ALDH2 polymorphism lowers alcoholic cirrhosis risk, but most patients misjudged their genotype. Early genetic screening may improve self-awareness and help prevent alcoholic cirrhosis.
METHODS: We enrolled 83 cirrhosis patients (45 alcoholic, 38 non-alcoholic) and 26 healthy volunteers from our hospital (Jan 2024-Feb 2025). Subjects were categorized into five groups based on ALDH2 and ADH1B polymorphisms and asked to predict their genotype before actual analysis using dried saliva specimens.
RESULTS: Self-recognition accuracy was 71.1% in alcoholic cirrhosis, 84.2% in non-alcoholic cirrhosis, and 85.7% in healthy controls (p<0.05). ALDH2 wild-type was found in 93.3% of alcoholic cirrhosis patients and 28.9% of non-alcoholic cirrhosis patients (p<0.01). ADH1B wild-type was more frequent in alcoholic cirrhosis (11.1% vs. 2.6%, p<0.05). Among alcoholic cirrhosis patients, 8.8% had both wild-types and showed severe liver dysfunction.
CONCLUSIONS: ALDH2 polymorphism lowers alcoholic cirrhosis risk, but most patients misjudged their genotype. Early genetic screening may improve self-awareness and help prevent alcoholic cirrhosis.
- Index Term 1: ALDH2 polymorphism
- Index Term 2: alcoholic cirrhosis