International Poster Session4 (JDDW)
October 31, 10:18–11:06, Room 15 (Kobe International Exhibition Hall No.1 Building Digital Poster Venue)
IP-20_G

Quantitative measurement of von Willebrand factor large multimers in obscure gastrointestinal bleeding

Haruna Horikawa1
Co-authors: Reo Kobayashi1, Ken Inoue1, Naoto Iwai1, Ryohei Hirose1, Toshifumi Doi1, Osamu Dohi1, Naohisa Yoshida1, Kazuhiko Uchiyama1, Tomohisa Takagi1, Takeshi Ishikawa1, Hodeyuki Konishi1, Hiroshi Nakase2, Atsushi Masamune3, Goro Matsumiya4, Naoki Ohmiya5, Hisanori Horiuchi6
1
Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine
2
Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine
3
Division of Gastroenterology, Tohoku University Graduate School of Medicine
4
Department of Cardiovascular Surgery, Chiba University Graduate School of Medicine
5
Department of Advanced Endoscopy, Fujita Health University
6
Nara City Nursing School
[Background] We have reported that the vWF large multimer index (vWF-LMI), a quantitative measure of vWF large multimers, is decreased in patients with severe aortic stenosis and that gastrointestinal bleeding is more frequent (N Engl J Med, 2023). However, the vWF-LMI in obstructed gastrointestinal bleeding (OGIB) remains unclear. We investigated the vWF-LMI in patients with OGIB. [Methods] This was a multicenter prospective clinical study (UMIN000044141). We examined the relationship between Bleeding Academic Research Consortium (BARC) bleeding criteria, Hb levels, and vWF-LMI. [Results] The BARC bleeding criteria classifications were Type 2 in 19 (37.3%) and Type 3 in 32 (62.7%). The mean vWF-LMI was 100.0±34.2%. In the analysis of the vWF-LMI <90% and ≥90% groups, the prevalence of Type 3 tended to be higher (76.5% vs. 55.9%, p=0.15). [Conclusion] vWF-LMI may be correlated with the severity of gastrointestinal bleeding and could be useful in determining the treatment strategy for OGIB.
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