International Session(Workshop)2(JSGE・JGES・JSGCS)
Fri. November 3rd   9:30 - 12:00   Room 9: Portopia Hotel Main Building Kairaku 3
Contributions of Transcriptome in Eosinophilic Esophagitis
Hiroki Sato1, Tetsuo Shoda1,2, Marc E. Rothenberg1,2
1Cincinnati Children's Hospital Medical Center, 2University of Cincinnati
Eosinophilic esophagitis (EoE) is an allergic inflammatory esophageal disorder with a complex underlying genetic and molecular etiology. The interest of the scientific community in EoE has grown considerably over the past three decades, and the understanding of disease mechanisms has greatly increased. So far, substantial progress has been made toward dramatically advancing our understanding of molecular factors contributing to disease pathogenesis through a variety of approaches with advances in technology. Of note, next-generation sequencing technologies (e.g., bulk and single-cell RNA sequencing) have aided in the identification of the distinct transcriptional signature in EoE with high accuracy and resolution. Also, the multiplex quantitative PCR assays [e.g., the EoE Diagnostic Panel (EDP)] has been particularly useful in diagnosing EoE, demonstrating significant reversibility in EoE-related genes, and correlating clinical information to define distinct EoE endotypes. Molecular analyses also have enabled us to assess the response of therapeutic interventions (e.g., Proton pump inhibitors), provide insights into clinical indices [e.g., the Index of Severity for EoE (I-SEE)], and evaluate the esophageal involvement in non-EoE eosinophilic gastrointestinal disorders for their similarities and differences from EoE.
In this presentation, we aim to provide both historical aspects and updates on the recent molecular advances in the understanding of EoE. We also highlight the multifaceted impacts of various findings that have shaped the current molecular landscape of EoE, providing insights that facilitate further understanding of the disease process.
Index Term 1: Eosinophilic esophagitis
Index Term 2: Transcriptome
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