International Session（Workshop）1(JSH・JSGE)
Thu. November 5th   9:40 - 12:00   Room 11: Portopia Hotel South Wing Topaz
IS-W1-5_H
 Correlation of pretreatment autophagy and cellular stress with the occurrence of post-SVR HCC in chronic hepatitis C, a propensity score matching analysis
Yuichi Honma1, Michihiko Shibata1, Masaru Harada1
1Third Department of Internal Medicine, University of Occupational and Environmental Health
Background: Hepatitis C virus (HCV) has been known to impair autophagy. The aim of this study was to assess relationship between the status of pretreatment autophagy and the occurrence of hepatocellular carcinoma (HCC) after the treatment for HCV infection.
Methods: From 2014 to 2019, a total of 183 HCV-related liver disease patients without history of HCC who received liver biopsy before direct-acting antivirals (DAAs) treatment and achieved SVR were enrolled. We used propensity score matching to reduce bias between patients who developed HCC (HCC group) and did not develop HCC (non-HCC group). Estimated variables were age, gender, alcohol consumption, diabetes mellitus, fatty liver, fibrosis in liver biopsy, albumin, total-bilirubin, AST, ALT, platelet count, AFP, type4 collagen, FIB-4 index, APRI before treatment and follow-up period. We performed immunostaining of LC3, p62, markers of endoplasmic reticulum stress (CHOP) and oxidative stress (HEL) in the liver biopsy specimen. Differences of immunohistochemical score (0-5) in each subject were analyzed using Mann-Whitney U-test
Results: Propensity score matching resulted in a matched sample size consisted of 5 in HCC group and 15 in non-HCC group. The expressions of LC3, p62, CHOP and HEL was higher in HCC group than non-HCC group.
Conclusion: The status of autophagy and stresses may correlate with incidence of post-SVR HCC occurrence.
Index Term 1: autophagy
Index Term 2: hepatocellular carcinoma
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