| International Session（Symposium）4(JSGE・JGES) |
| Fri. November 22nd 9:30 - 12:00 Room 11: Portopia Hotel South Wing Topaz |
| Higher abundance of Streptococcus in upper gastrointestinal mucosa associated with symptoms in patients with functional dyspepsia | |||
| Akifumi Fukui1, Tomohisa Takagi2, Yuji Naito2 | |||
| 1North Medical Center, Kyoto Prefectural University of Medicine, 2Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine | |||
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| Objective: Functional dyspepsia (FD) is associated with poor health-related quality of life. Recent evidence suggests that the main pathogenesis suspect is the gut mucosa-associated microbiota (MAM). However, little is known about the MAM in FD subjects. The aim of this study was to clarify the relationship between upper gastrointestinal symptoms in FD and the characteristics of the gastrointestinal MAM. Design: Five mucosa samples from the upper gut (intraoral, esophagus, gastric body, gastric antrum, and duodenum) were collected with a brush under endoscopic examination from FD and healthy control subjects. MAM profiles of each sample were analysed by 16S-rRNA V3-V4 gene sequences. Questionnaires were used to assess gastrointestinal symptoms in FD. Results: Between FD and healthy control subjects, although the comparison of MAM α-diversity showed no significant differences, the structure of MAM (β-diversity) was clearly different. Only the phylum Firmicutes was increased in FD compared to healthy control subjects in all sites of the upper gut. At the genus level, Streptococcus was significantly increased in all sites in the upper gut in FD. The relative abundance of Streptococcus was positively correlated with upper gastrointestinal symptoms in each upper gut group. Conclusion: Taken together, these findings suggest that Streptococcus is a bacterium strongly correlated with upper gastrointestinal symptoms in FD. |
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Index Term 1: Mucosa-associated microbiota Index Term 2: Functional dyspepsia |
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