| International Session（Symposium）4(JSGE・JGES) |
| Fri. November 22nd 9:30 - 12:00 Room 11: Portopia Hotel South Wing Topaz |
| Pathophysiology of functional dyspepsia, a look to both sides of the epithelium | |||
| Ricard Farre | |||
| Catholic University of Leuven | |||
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| The gut barrier function is comprised by three major lines of defense: a) the biological barrier, which is made up of commensal microbiota; b) the immune barrier; and c) the mechanical barrier, consisting of the intestinal epithelial cells and by the capillary endothelial cells. A proper functioning of these barriers is crucial for maintaining the correct homeostasis. The mechanical barrier and the immune barriers avoid the passage of luminal content (e.g. commensal microbiota, food antigens, bile acids) to deeper layers of the GI tract that can be detrimental for maintaining a normal physiology. Alterations of these barriers are present in functional dyspepsia and can play an important role on its pathophysiology. In this talk, I will discuss about the current knowledge about the pathophysiology of functional dyspepsia and its implications. |
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Index Term 1: pathophysiology Index Term 2: functional dyspepsia |
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