| International Session（Symposium）3(JSGS・JSGE・JSH・JSGCS) |
| Fri. November 22nd 14:00 - 16:30 Room 2: Kobe International Exhibition Hall No.2 Building Hall (South) |
| Intraoperative peritoneal liquid biopsy as a predictive biomarker for recurrence after curative gastrointestinal cancer surgery | |||
| Satoshi Murata1, Katsushi Takebayashi2, Masaji Tani2 | |||
| 1Cancer Center, Shiga University of Medical Science Hospital, 2Department of Surgery, Shiga University of Medical Science | |||
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| Background The aim of this study was to evaluate the peritoneal liquid biopsy obtained during potentially curative (R0) GI cancer surgery as a predictive biomarker for recurrence. Methods Consecutive patients with pancreatic cancer (PC) (n=52) or advanced gastric cancer (GC) (≥pT2) (n=100) who underwent R0 surgery between 2010 and 2017 were enrolled. Peritoneal washing (PW) fluid before (PW-Pre) and after surgery (PW-Post) was collected and cultured to detect viable cancer cells. Results In 52 PC patients with negative for PW-Pre-cytology (CY0), 19 (36.5%) showed positive for cancer cell culture [PW-Pre-CCC(+)]. In 33 patients with PW-Pre-CCC(-), 25 (75.8%) developed PW-Post-CCC(+), and 8 (24.2%) remained at PW-Post-CCC(-). No clinicopathological difference was observed between PW-CCC(+) and PW-CCC(-) cohorts. Recurrences occurred in 32/44 (72.7%) patients with PW-CCC(+) and 1/8 (12.5%) with PW-CCC(-). Multivariate analysis showed PW-CCC(+) as an independent risk factor for recurrence (Odds:38.7, P=0.003). In advanced GC patients with CY0 and PW-Pre-CCC(-), 53 showed PW-Post-CCC(+) and 47 had PW-Post-CCC(-). No clinicopathological difference was observed between the two cohorts. Recurrences occurred in 20 (37.7%) patients with PW-Post-CCC(+), but not (0%) in patients with PW-Post-CCC(-). Multivariate analysis showed PW-Post-CCC(+) was an independent risk factor for recurrence (Odds:60.3, P=0.005). Conclusion PW-CCC as peritoneal liquid biopsy is a promising predictive biomarker for recurrence after R0 PC or GC surgery. |
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Index Term 1: recurrence biomarker Index Term 2: peritoneal liquid biopsy |
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