| Proton-pump inhibitors (PPIs) are among the most widely used drugs worldwide. However, there care increasing concerns about the safety of PPI use. Currently, there are is little guidance on whether, who and how long-term PPI therapy be terminated. The decision should be based on the indications of PPI use, an assessment of the risks of stopping PPI, and the availability of alternative therapy. This lecture aims to: 1. provide an overview of the current evidence of PPI-associated adverse outcomes; 2. identify who should stop long-term PPI therapy; and 3.suggest how one can reduce or stop chronic PPI therapy. |
