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Invited Lecture International Session
(Symposium) International Session
(Workshop) Symposium Panel Discussion Workshop International Poster Session
Panel Discussion 6 (JSH・JSGE・JSGS)
Fri. November 2nd   9:00 - 12:00   Room 2: Kobe International Exhibition Hall No.2 Building Hall South
PD6-12
 MHC class I chain-related A genetic predispositions and associated membrane protein expression in hepatocellular carcinoma
Chung-Feng Huang1, Ming-Lung Yu1
1Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital
Background/Aims MHC class I chain-related A (MICA) genetic variants have been associated with hepatocellular carcinoma (HCC). Its association with the expression of membrane-bound MICA (mMICA) on the cancer cell is elusive.
Methods MICA single nucleotide polymorphism (SNP) at rs2596542 of were tested in 193 HCC patients. The corresponding mMICA expression on the cancer was evaluated by immunochemistry microarray.
Results The presentation of mMICA in the tumor part and non-tumor part was 33.1+21.4 % and 30.4+16.9 %, respectively (P=0.18), which correlated well to each other (P<0.001, r=0.364). Patients with SNP rs2596542 A allele had significantly lower mMICA expression compared to those with GG genotype in the tumor (24.7+15.1 % vs. 41.5+23.4 %, P<0.001). Linear regression analysis revealed that the only factor correlated to mMICA expression was the carriage of MICA rs2596542 A allele (β:-0.396; 95 % confidence intervals [CI]: -22.744- -10.991; P<0.001). Logistic regression analysis also demonstrated that A allele carriage was the only factor associated with low mMICA expression (<30 %) in the tumor (odds ratio/CI: 0.16/0.08-0.30, P<0.001). Compared to the carriage of GG genotype, the fact that low mMICA expression in A allele carriers existed only in the tumor part (24.7+15.1 vs. 41.5+23.4, P<0.001) but not non-tumor part (31.5+16.9 % vs. 29.4+17.0, P=0.39).
Conclusions The carriage of MICA rs2596542 A allele was independently associated with low mMICA expression in the tumor, which may lead to poor immune surveillance and increase HCC risk.
Index Term 1: mMICA
Index Term 2: HCC
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