October 24 (Fri.), 14:45–15:46, Room 15 (Kobe International Exhibition Hall No. 3 Digital Poster Session Venue)
IP-21

End-stage Renal Disease Affects the Outcome of Peptic Ulcer Bleeding

C. H. Chiu1
Co-authors: W. C. Tai2, L. S. Lu2, C. H. Lee1,3, C. T. Lee3, S. K. Chuah2
1
Division of General Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine
2
Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital
3
Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital
Patients suffering from peptic ulcer bleeding (PUB) who have end-stage renal disease (ESRD) may result in more adverse outcomes. This study aimed to investigate the outcomes of ESRD patients with PUB after being initial endoscopic hemostasis.
515 patients who received successful endoscopic treatment initially for PUB were enrolled and sorted into 3 groups: ESRD on dialysis (ESRD group) (n=43); chronic kidney disease (CKD) not requiring dialysis (CKD group) (n=163) and normal kidney function group (normal group) (n=309).
362 were male. The overall rebleeding rates were higher in the CKD group but did not reach significant statistical difference (18.1 vs. 22.1 % vs. 23.3%, p=0.495). The mortality rates for ESRD group(23.3%; n=10) were significantly higher than CKD group(13.5%; n=22) and normal group (10.4%; n=32), respectively (p=0.049). The ESRD group had an odds ratio of 2.62 (95% CI, 1.18-5.81; p=0.018) for mortality compared with the normal group. The significant predictors for mortality were lower hemoglobin and platelet levels, larger ulcer sizes, higher Rockall scores and longer time-to-scope period.
Conclusions: ESRD dialysis patients suffering from PUB encounter more severe clinical status and higher mortality rates despite successful initial endoscopic hemostasis.