Detectability of colorectal polyp using a novel endoscopic system with blue laser imaging: a multicenter randomized controlled trial

Background & Aim: A LASER endoscopic system has been developed by FUJIFILM. It has a bright narrow band imaging observation named Blue laser imaging (BLI)-bright. This study aimed to evaluate the efficacy of BLI-bright for detecting colorectal lesions.Patients and Methods: This study was prospectively designed as a randomized controlled trial at eight institutions in Japan from July, 2014 to June 2015 (UMIN 000014555). We enrolled consecutive patients aged >39 years, who had been referred for polypectomy, surveillance, or screening. The participants were randomly assigned to 2 groups: white light imaging (WLI) observation with conventional xenon light source (WLI group) or BLI-bright observation (BLI group). The primary outcome was the number of adenomatous lesions detected per patient.Results: Finally, the WLI and BLI groups comprised 474 and 489 patients, respectively. The number of adenomatous lesions detected per patient was significantly higher with BLI than with WLI (WLI 1.01± 1.36, BLI 1.27± 1.73; P=0.008). The total number of lesions detected per patient was also significantly higher with BLI than with WLI (WLI 1.43± 1.64, BLI 1.84 ± 2.09; P=0.001). Conclusion: The endoscopic system using BLI-bright improved the detectability of adenomatous lesions compared with WLI.